Olimp HMB - 450 caps
OLIMP HMB - 450 caps HMB is a metabolite of Leucine, however, only a small amount of Leucine actually converts to HMB – so to benefit from everything that HMB has to offer, it is important to supplement with it...
€39.99 €31.99
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HMB Supplement Biotech USA (150 Mega Capsules)
Amino Acid Supplement BIOTECH USA HMB Capsules HMB is a metabolite of the amino acid Leucine. HMB is used to help people to achieve better training gains and improve body composition. Supplementing HMB may enhance exercise performance by preserving lean muscle tissue and...
€24.99 €19.99
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HMB Mega Caps 1250 Olimp - 120 caps
Olimp HMB Mega Caps 1250 Olimp HMB (beta-hydroxy-beta-methylbutyrate) is a bioactive nutrient belonging to the group of branched short-chain fatty acids, considered by some sources as a vitamin-like factor (similar to vitamins in terms of its effects), found naturally –...
€24.99 €19.99
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HMB 1000 Supplement BIOGENIX (120 caps)
Increase Lean Muscle Mass BIOGENIX HMB 1000 Do you train hard to achieve satisfactory results? If you want to build a valuable musculature, reach for BIOGENIX HMB 1000. It is a dietary supplement that: Shows a strong effect Protects muscles against...
€24.99 €17.95
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HMB Powder 210g Ostrovit
OstroVit HMB Powder HMB OstroVit benefits: OstroVit HMB is the highest quality, modern supplement, consisting of only one substance, which is HMB. The product has been fragmented by subjecting it to the micronization process, which provide even better absorbability. 210 g...
€15.99 €13.99
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HMB Fatty acids TREC NUTRITION (70 caps)
TREC NUTRITION Supplement HMB Sport Formula (70 caps) Improves Body Composition, Lean Mass And Muscular Strength! Complete protection from catabolism Sculpted and muscular silhouette Pure HMB capsules HMB supplement capsules contain highest quality β-Hydroxy β-Methylburate HMB. This short-chain fatty acid is...
€14.99 €9.99
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What is HMB?

HMB (short for β-Hydroxy β-Methylbutyrate) is a metabolite of the amino acid leucine that, along with KIC (α keto-isocaproate) and isovaleryl-CoA, mediate the effects of leucine. Approximately 5% of dietary leucine is oxidized into HMB, and HMB appears to be the main metabolite of leucine that more effectively prevents the breakdown of muscle protein.

When compared to leucine, HMB appears to be significantly more potent on a gram per gram basis at attenuating the rate of muscle protein breakdown but is less effective than leucine at inducing muscle protein synthesis. Due to this, HMB is marketed as an anti-catabolic agent (purposed to reduce the rate of muscle breakdown) rather than an anabolic agent (purposed to increase muscle mass).

Human trials don't normally tend to be structured to properly assess the effects of HMB, as most of the studies are a standard diet paired with an exercise regimen investigating the role of HMB in promoting muscle protein synthesis (of which it is similar to leucine in the sense that there are positive results, but quite unreliably so); the limited evidence that assesses HMB during periods of muscle loss are either underpowered or not in athletes.

HMB, currently, appears to be a pretty interesting supplement for the purpose of reducing muscle wasting during periods where muscle atrophy is accelerated (cachexia, AIDS, bedrest) and should theoretically work in athletes on a calorie restricted diet but is not fully established for this role yet (which is a notable issue, since glutamine has a large dichotomy between clinical and healthy populations).

How to take HMB?

Supplementation of HMB tends to be in the dosage range of 1-3g daily for the purpose of reducing muscle mass losses over time (anti-catabolic). As HMB is said to be 20-fold more potent than leucine for this purpose, it is seen as equivalent to 20-60g of leucine supplementation.

For the purpose of muscle protein synthesis, HMB and leucine are fairly equivalent if not the latter (leucine) being more potent on a gram basis. HMB is not advised for inducing muscle protein synthesis since leucine is likely more effective as well as cheaper.

Supplementation of HMB prior to an exercise session would require the usage of an HMB free acid rather than a calcium salt, and the above dosage range still holds. For this specific purpose, HMB is to be taken 30-45 minutes before a workout.

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